nanobody
Nanobody
What is Nanobody?
- Heavy chain only, single domain antibody
- It is naturally in the serum of camelidae (Camelid, Lama, Alpaca etc.)
- Conventional Antibody
- Heavy Chain Only Antibody
| Conventional antibody | Nanobody | |
|---|---|---|
| Mechanism | ADCC, Neutralizing antibody, Effector moiety | |
| Affinity | 10-9 ~ 10-12 Kd | |
| Origin | Mouse, Human | Camelidae |
| Immunogenicity | Need humanization | High sequence homology with human (~80%) |
| Structure | Heavy chain + Light chain double strand | Heavy chain single strand |
| Size | 150 kDa | 10 ~ 15 kDa : Various targets |
| Solubility & Stability | Low | High : Various administration routes |
| Half-life in serum | Fixed | Controllable |
| Manufacturing | High cost, system limited | Low cost, system unlimited |
NanoMab® is Shaperon’s proprietary nanobodies that contain the unique structural and functional properties of single domain antibody
| Platform Technology | ||
|---|---|---|
| Immunization | Alpaca immunization | Immunizations specific to targets |
| Immune Library | Medusa Library Technology | High-Valency Library construction |
| Biopanning/ Screening |
HERA Panning System Technology | High-Fidelity Multiplex Screening |
| λ Panning System Technology | High-Throughtput Screening | |
| Cell line | RCB & MCB CHO cell line manufacturing technology | Collaboration with Horizon Discovery Corp. |